Evaluation of focal damage in the retinal pigment epithelium layer in serous retinal pigment epithelium detachment
نویسندگان
چکیده
منابع مشابه
The genomic response of the retinal pigment epithelium to light damage and retinal detachment.
The retinal pigment epithelium (RPE) plays an essential role in maintaining the health of the retina. The RPE is also the site of pathologic processes in a wide variety of retinal disorders including monogenic retinal dystrophies, age-related macular degeneration, and retinal detachment. Despite intense interest in the RPE, little is known about its molecular response to ocular damage or diseas...
متن کاملFollow-up study of detachment of the retinal pigment epithelium.
To determine the clinical course of untreated retinal pigment epithelial detachment we reviewed data from 50 eyes of 42 patients followed up for an average of 29 months without photocoagulation. In 14 eyes with avascular lesions, in patients under 50 years of age, all had a final vision of 20/30 or better. None developed neovascularisation or haemorrhage. In 17 eyes with avascular lesions in pa...
متن کاملRetinal light damage reduces autofluorescent pigment deposition in the retinal pigment epithelium.
Lipofuscin in the retinal pigment epithelium (RPE) is thought to be derived from phagocytosed photoreceptor outer segment disc membranes. Based on this hypothesis, one would predict that the rate of lipofuscin deposition in the RPE would be proportional to the density of photoreceptor cells in the retina. In previous studies it was demonstrated that specific loss of photoreceptor cells due to a...
متن کاملDetection of Retinal Pigment Epithelium-Specific Antibody in iPSC-Derived Retinal Pigment Epithelium Transplantation Models
Antibody-mediated rejection is characterized by donor-specific antibody produced by B cells. However, to our knowledge, B cell invasion and antibody in the inflamed retina after transplantation of retinal pigment epithelial (RPE) cells has not been reported. To determine if RPE transplantation could be performed using allografts, we established in vivo immune rejection models with induced pluri...
متن کاملObservations on the retinal pigment epithelium and retinal macrophages in experimental retinal detachment.
After experimental retinal detachment in rabbits macrophages are a prominent feature in the subretinal space or within the retina. Two sources for these macrophages are identified. The retinal pigment epithelium (RPE) may undergo metaplasia and actively 'bud'; the evolving macrophage is then formed by a vitreal protrusion of the cytoplasm of an RPE cell which is 'nipped off' by lateral protrusi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-39688-z